Podcasts from The Cochrane Library

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Haemodiafiltration, haemofiltration and haemodialysis for end-stage kidney disease

Wed, 06/22/2016 - 14:13

There is considerable interest in innovative dialysis therapies for people with kidney failure, in particular to remove larger circulating toxins that are poorly removed by standard haemodialysis, which are associated with higher mortality and infection. In an updated Cochrane review, published in May 2015, Suetonia Palmer from Christchurch in New Zealand and colleagues, brought together the studies of the impact of haemodiafiltration on patient outcomes. She tells us what they found in this evidence pod.

Care delivery and self management strategies for adults with epilepsy

Mon, 05/23/2016 - 18:37

Epilepsy affects tens of millions of people around the world and alongside many trials and reviews of drugs and other treatments, are studies that have tested more complex strategies. In an updated Cochrane Review from February 2016, Peter Bradley, from Public Health Wales in the UK. and colleagues look at the evidence for some of these. He tells us what they found in this evidence pod.

Health system and community level interventions for improving antenatal care coverage and health outcomes

Mon, 05/23/2016 - 18:21

One of the major challenges facing the health systems of low and middle-income countries is to improve the antenatal care for pregnant women. In a new Cochrane Review from December 2015, Lawrence Mbuagbaw, from the Yaoundé Central Hospital in Cameroon and McMaster University in Canada, and colleagues have brought together the evidence on health system and community level interventions.

Effectiveness and safety of devices designed to close femoral artery puncture sites

Mon, 05/23/2016 - 17:14

A major development in health care in recent decades has been the ability of doctors to access difficult to reach parts of a patient’s body through their blood vessels. These endovascular procedures require access to the inside of an artery and need to finish by closing the hole that was created to enter the artery. The lead author of a new Cochrane Review in March 2016, Lindsay Robertson, from Freeman Hospital in Newcastle upon Tyne in the UK tells us about the evidence for one of the ways to do this.

Interventions for treating severe nausea and vomiting during pregnancy (hyperemesis gravidarum)

Thu, 05/12/2016 - 14:37

Many pregnant women will experience some degree of morning sickness, but, for some, the nausea and vomiting will be much worse. Rupsa Boelig from the Thomas Jefferson University Hospital in Philadelphia, USA tells us about the findings of a May 2016 Cochrane Review of interventions to help them.

Analysis bias

Tue, 05/10/2016 - 18:34

Mike Clarke, podcast editor for Trials Change Lives, based at the Northern Ireland Hub for Trials Methodology Research in Queen’s University Belfast discusses the general need to keep biases out of trials by looking at the specific challenge of minimizing bias when the results are being analyzed.

Read more on this topic in the James Lind Library.

This podcast is part of the Trials Change Lives initiative, developed by the MRC Network of Hubs for Trials Methodology Research in partnership with the Northern Ireland Network for Trials Methodology Research. Free posters are available to download methodologyhubs.mrc.ac.uk/research/trials-change-lives.

Exercise trials

Mon, 05/09/2016 - 19:33

Being physically active can have beneficial effects on our physical and mental health, but the UK population as a whole doesn’t meet the current Government guidelines. Dr Ruth Hunter, Lecturer in Physical Activity and Public Health/NIHR Career Development Fellow, UKCRC Centre of Excellence for Public Health, at Queen’s University Belfast in Northern Ireland describes some of the innovative approaches that her team are testing to encourage people to be more active.

This podcast is part of the Trials Change Lives initiative, developed by the MRC Network of Hubs for Trials Methodology Research in partnership with the Northern Ireland Network for Trials Methodology Research. Free posters are available to download methodologyhubs.mrc.ac.uk/research/trials-change-lives.

Aspirin and stroke trials

Mon, 05/09/2016 - 16:48

Peter Sandercock from the University of Edinburgh in Scotland tells us how two randomised trials, with 40,000 patients in more than 800 hospitals, changed clinical practice for tens of millions of people with a stroke.

This podcast is part of the Trials Change Lives initiative, developed by the MRC Network of Hubs for Trials Methodology Research in partnership with the Northern Ireland Network for Trials Methodology Research. Free posters are available to download methodologyhubs.mrc.ac.uk/research/trials-change-lives.

Workplace interventions for reducing sitting time at work

Fri, 05/06/2016 - 14:48

Most people would probably benefit from increasing their physical activity. One way to achieve this might be reducing the amount of time we spend sitting down at work. In January 2015, a new Cochrane Review examined the evidence on interventions that might help and this was updated with several new studies in March 2016. We asked one of the authors, Jos Verbeek from the Finnish Institute of Occupational Health to tell us about the need for the review and its latest findings.

C​linical Trials Units

Thu, 05/05/2016 - 20:11

A key part of the infrastructure for clinical trials in the UK is provided by more than 50 Clinical Trial Units spread across the country. We asked Julia Brown, Director of the Clinical Trial Units’ Network to tell us about their work and their contribution to ensuring that trials change lives.

This podcast is part of the Trials Change Lives initiative, developed by the MRC Network of Hubs for Trials Methodology Research in partnership with the Northern Ireland Network for Trials Methodology Research. Free posters are available to download methodologyhubs.mrc.ac.uk/research/trials-change-lives.

GP trials

Wed, 05/04/2016 - 18:50

General practitioners are key to both the conduct of clinical trials and the uptake of their results. Carol Sinnott a GP from Cork in Ireland tells us how they have helped her to change lives.

This podcast is part of the Trials Change Lives initiative, developed by the MRC Network of Hubs for Trials Methodology Research in partnership with the Northern Ireland Network for Trials Methodology Research. Free posters are available to download methodologyhubs.mrc.ac.uk/research/trials-change-lives.

Interventions for sexual dysfunction following treatments for cancer

Wed, 05/04/2016 - 16:09

Improvements in the diagnosis and treatment of cancer mean that more people are living with and surviving cancer, which brings with it a need to identify interventions that can help with any long-term complications. In this Evidence Pod, Bridget Candy from Marie Curie Palliative Care Research Department at UCL in London, England describes the findings of a new Cochrane Review from February 2016 which examined the randomised trials of interventions for sexual dysfunction in women.

Clinical trials for the NHS

Tue, 05/03/2016 - 22:44

In the UK, the main public funder of healthcare research is the National Institute for Health Research, or NIHR. In this Evidence Pod for Trials Change Lives, we asked Hywel Williams, Director of the NIHR’s Health Technology Assessment programme to outline the importance of clinical trials to this programme and health and social care more generally.

This podcast is part of the Trials Change Lives initiative, developed by the MRC Network of Hubs for Trials Methodology Research in partnership with the Northern Ireland Network for Trials Methodology Research. Free posters are available to download methodologyhubs.mrc.ac.uk/research/trials-change-lives.

Vaccines for preventing herpes zoster (shingles) in older adults

Thu, 04/28/2016 - 14:26

Among the updated Cochrane Reviews in March 2016 is one from a team of researchers in Brazil looking at the effects of vaccines for Herpes Zoster. Anna Gagliardi (centre), with her co-authors Brenda Gomes Silva (left) and Maria Regina Torloni, from the Department of Geriatrics and Gerontology at the Federal University of São Paulo in Brazil describes their findings in this evidence pod.

Improving outcomes for people with multiple chronic conditions

Wed, 04/20/2016 - 18:28

Many people with chronic disease have more than one illness, which is referred to as multimorbidity. Susan Smith from the Department of General Practice at the Royal College of Surgeons in Ireland describes an updated, March 2016, Cochrane Review which sought out evidence on interventions that might help.

Prolonged antibiotics for purulent bronchiectasis in children and adults

Tue, 04/12/2016 - 13:42

The Cochrane Airways group has produced more than 300 full reviews, across a wide range of lung problems. One of these is bronchiectasis and an updated review from August 2015 examines the effects of long-term antibiotic therapy. Khin Hnin, from Flinders University in Adelaide Australia, summarizes the findings in this evidence pod.

Techniques for assisting difficult caesarean section

Fri, 04/08/2016 - 14:48

Caesarean section is probably one of the commonest surgical procedures and is usually fairly straightforward. However, problems can arise and an updated Cochrane Review in January 2016 looks at interventions that might help in those circumstances. Heather Waterfall, from Lyell McEwin Hospital in Elizabeth, South Australia describes the findings.

Tests for imaging the optic nerve and its fibres for diagnosing glaucoma

Mon, 04/04/2016 - 14:07

The Cochrane Database of Systematic Reviews contains dozens of reviews of the accuracy of diagnostic tests and imaging, along with the thousands of reviews of the effects of treatments. In November 2015, these were added to by a new review of imaging devices for glaucoma and Gianni Virgili, from the University of Florence in Italy, tells us about the findings in this Evidence Pod.

Amiodarone for preventing sudden cardiac death

Wed, 03/30/2016 - 21:20

A new Cochrane Review from December 2015 examines the effects of the drug amiodarone on the prevention of sudden cardiac death. The lead author, Juan Carlos Claro, from the Pontificia Universidad Católica de Chile, in Santiago, Chile, describes the review and its findings in this Evidence Pod.

Light therapy for prevention of winter depression

Wed, 03/30/2016 - 21:02

Many people experience the “winter blues”, but some suffer from seasonal affective disorder, which has a major impact on their quality of life. Some people have turned to light therapy to try to prevent it and a team of researchers from Austria and the USA published the Cochrane Review of the evidence in November 2015. Lead author, Barbara Nussbaumer, from the Danube University Krems in Austria, tells us more.

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