Podcasts from The Cochrane Library
High blood pressure is a chronic condition associated with an increased risk of cardiovascular disease and death. Over the last two decades, the Cochrane Hypertension Group has produced numerous reviews of ways to treat it, including one of the effects of a class of drugs called renin inhibitors. The review was updated in April 2017 and we asked the lead author, Vijaya Musini from the University of British Columbia in Vancouver Canada, to tell us about the latest findings.
The Cochrane Tobacco Addiction Group at the University of Oxford in the UK is one of the oldest groups working on Cochrane Reviews. It has produced dozens of these during the last two decades and, in 2016, it embarked on a project to identify the top priorities for future research into tobacco control. After an extensive and intensive period of information gathering and processing, the findings were published in September 2017. We asked Jamie Hartmann-Boyce, Senior Researcher and Managing Editor in the Cochrane group to tell us about the global importance of what they found.
Ultrasonography versus computed tomography scan for endoleak detection after endoluminal abdominal aortic aneurysm repair
An abdominal aortic aneurysm is a life threatening condition and patients might need lifelong monitoring after treatment. Ultrasonogaphy is sometimes used for this and a new Cochrane Review from June 2017 looks at its accuracy. The review was done by a team from Italy and Kathy Mahan from the Cochrane Neurosciences group, also based in Italy, tells us what they found.
Studies have shown that up to half of adult patients in hospital suffer from malnutrition, and a new Cochrane Review from May 2017 examines the evidence on the effects of nutrition support. We asked Joshua Feinberg, from the Copenhagen Trial Unit in the Rigshospitalet in Denmark, who led the team of 20 authors from Denmark and China to tell us what they found.
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants
Sepsis is the commonest cause of death for new born babies worldwide. Mohan Pammi and Gautham Suresh from Baylor College of Medicine in Houston in the USA updated the Cochrane review of the evidence on the use of lactoferrin, in June 2017. Mohan describes the latest findings.
Non-invasive ventilation for people with respiratory failure due to exacerbation of chronic obstructive pulmonary disease (COPD)
The respiratory illness, chronic obstructive pulmonary disease, or COPD, is a major health burden for patients and healthcare systems, and there are several Cochrane Reviews examining the evidence for various ways to manage it. These were added to in July 2017 by the updating of a review last done in 2004 which looks at the evidence for the use of positive pressure breathing support during exacerbations. This was led by Dr. Christian Osadnik, from Monash University in Melbourne in Australia, who tells us what they found in this podcast.
Many people take vitamin C with a view to preventing, treating or helping with various conditions and there are Cochrane Reviews of its effects in diabetes, pregnancy and for some lung conditions. In March 2017, these were added to with a review of whether vitamin C can prevent cardiovascular disease and we asked the first author, Lena Al-Khudairy from Warwick Medical School in the UK to tell us more.
There are now more than 80 full Cochrane Reviews of a wide variety of interventions for people with cystic fibrosis. In May 2017, one of these was updated by Lisa Morrison and Stephanie Milroy from the Queen Elizabeth Hospital in Glasgow in Scotland to bring together the latest evidence on the effects of oscillating devices. Lisa tells us what they found in this podcast.
Diabetic macular oedema is a common complication of diabetes, in which damage to the blood vessels at the back of the eye leads to swelling. Lucentis, Eylea and Avastin are three antiangiogenic drugs that can be injected into the eye to treat the blood vessels and reduce the swelling. In June 2017, Gianni Virgili from the University of Florence in Italy, and colleagues, updated their Cochrane review of these drugs and used a network meta-analysis to compare their effects.
Alongside the several existing Cochrane Reviews of steroids for adults and children with asthma, in April 2017 the Cochrane Airways Group added a new review of interventions to improve adherence to these drugs. We asked Rebecca Normansell (left) and Liz Stovold, both authors on the review and members of staff with Cochrane Airways, to tell us more in this podcast, starting with Rebecca.
Several Cochrane Reviews examine the effects of treatments for sickle cell disease, which can cause a huge burden for patients and their families. In a new addition to these in April 2017, Jo Howard from Guy's and St Thomas' Hospitals in London in the UK and colleagues focused on the drug hydroxyurea, which is also known as hydroxycarbamide. She tells us what they found in this podcast.
Statins are very widely prescribed to lower cholesterol and it’s important to know the best ways to help patients to take them. In an updated Cochrane Review from December 2016, Mieke van Driel from the University of Queensland in Australia examines the evidence, and she tells us more in this podcast.
The Cochrane Work Group prepares reviews of a wide variety of topics related to ways in which workers’ health and safety, and wellbeing could be improved. These were added to in January 2017 with a review of interventions intended to prevent bullying in the workplace. The lead author, Patricia Gillen from Ulster University in Northern Ireland tells us what they found in this podcast.
A range of injuries and disabilities can lead to stiffening in the soft tissues or muscles of the patient’s limbs, causing problems with movement, called contractures. One of the widely used treatments is stretch, but does it work? Lisa Harvey from the University of Sydney in Australia and colleagues tried to find out in an updated Cochrane Review in January 2017, and she tells us more in this podcast.
Cochrane Stroke is one of the oldest Cochrane groups and has produced nearly 200 reviews of various interventions for stroke and other types of brain injury. An update to one of these, in January 2017, examines the evidence on music interventions and lead author Wendy Magee from the Boyer College of Music and Dance at Temple University in Philadelphia, USA, tells us more in this podcast.
Fixed daily dose of a low molecular weight heparin compared with an adjusted dose of unfractionated heparin for treating blood clots in the deep veins
Venous thromboembolism is a common and potentially life-threatening condition in which a clot forms in the veins of the leg or pelvis or moves up to the lungs where it blocks a blood vessel. Heparin is one of the treatments and an updated Cochrane Review from February 2017 examines the evidence of its effects. Lindsay Robertson from the Freeman Hospital in Newcastle upon Tyne in the UK tells us about these latest findings.
Most Cochrane Reviews focus primarily on the intended effects of interventions, but some are designed to investigate the potential harms. One such review was published in November 2016 to examine the effects of anti-epileptic drugs during pregnancy. The lead author, Rebecca Bromley from the Institute of Human Development at the University of Manchester in the UK tells us more in this podcast.
Root canal treatment is a common procedure in dentistry, and requires one or more visits to the dentist. In an updated review in December 2016, the Cochrane authors have brought together the trials that compared different numbers of visits and we asked the lead author, Maddalena Manfredi from the University of Parma in Italy to tell us what they found.
Combined intermittent pneumatic leg compression and medication for the prevention of deep vein thrombosis and pulmonary embolism
The single most common, preventable cause of in-hospital death is a hospital-acquired venous thromboembolism; making thi an important target for prevention when people are admitted to hospital. An updated Cochrane Review from September 2016 looks at the evidence for one of the possible interventions, a combination of intermittent pneumatic leg compression and drugs to prevent blood clots. Hayley Hassan from the Cochrane Central Executive Team, on behalf of the authors, tells us more.
Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for cystic fibrosis
Cystic fibrosis is an inherited condition, associated with mutation of a specific gene involved in the movement of salt across cells. One of the proposed treatments that targets a particular type of this mutation is a drug called Ataluren, which was the subject of a new Cochrane Review in January 2017. One of the authors, Kevin Southern from the Department of Women's and Children's Health at the University of Liverpool in the UK, describes the available evidence in this podcast.