National Eye Institute News and Events

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Updated: 7 min 19 sec ago

New light sensing molecule discovered in the fruit fly brain

Wed, 05/10/2017 - 14:51

Six biological pigments called rhodopsins play well-established roles in light-sensing in the fruit fly eye. Three of them also have light-independent roles in temperature sensation. New research shows that a seventh rhodopsin, Rh7, is expressed in the brain of fruit flies where it regulates the fly’s day-night activity cycles. The study appears in Nature and was funded by the National Eye Institute, part of the National Institutes of Health.

Avastin as effective as Eylea for treating central retinal vein occlusion

Wed, 05/10/2017 - 09:56

Monthly eye injections of Avastin (bevacizumab) are as effective as the more expensive drug Eylea (aflibercept) for the treatment of central retinal vein occlusion (CRVO), according to a clinical trial funded by the National Eye Institute (NEI), part of the National Institutes of Health. After six monthly injections, treatment with either drug improved visual acuity on average from 20/100 to 20/40.

Systemic therapy outperforms intraocular implant for treating uveitis

Sun, 05/07/2017 - 16:31

Systemic therapy consisting of corticosteroids and immunosuppressants preserved vision of uveitis patients better – and had fewer adverse outcomes – than a long-lasting corticosteroid intraocular implant, according to a clinical trial funded by the National Eye Institute (NEI). After seven years, visual acuity on average remained stable among participants on systemic therapy but declined by an average of six letters (about one line on an eye chart) among participants who had the implant. NEI is part of the National Institutes of Health.

Moving future regenerative therapies for blinding eye diseases to the clinic

Sun, 04/30/2017 - 14:46

A new report outlines steps to bringing future regenerative therapies for blinding diseases of the retina to patients. The retina is the light-sensitive tissue in the back of the eye. When stimulated, retinal neurons send visual information to the brain. Diseases like age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy can irreparably damage or destroy these neurons, which fail to regenerate on their own.

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Moving future regenerative therapies for blinding eye diseases to the clinic

Sun, 04/30/2017 - 14:46

A new report outlines steps to bringing future regenerative therapies for blinding diseases of the retina to patients. The retina is the light-sensitive tissue in the back of the eye. When stimulated, retinal neurons send visual information to the brain. Diseases like age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy can irreparably damage or destroy these neurons, which fail to regenerate on their own.

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Helping the retina regenerate

Thu, 03/30/2017 - 21:25

A new report gives recommendations for regenerating retinal ganglion cells (RGCs), crucial neurons in the back of the eye that carry visual information to the brain. Authored by Monica Vetter, Ph.D., University of Utah, and Peter Hitchcock, Ph.D., University of Michigan, the report stems from a 2016 workshop sponsored by the National Eye Institute (NEI) Audacious Goals Initiative (AGI).

Helping the retina regenerate

Thu, 03/30/2017 - 21:25

A new report gives recommendations for regenerating retinal ganglion cells (RGCs), crucial neurons in the back of the eye that carry visual information to the brain. Authored by Monica Vetter, Ph.D., University of Utah, and Peter Hitchcock, Ph.D., University of Michigan, the report stems from a 2016 workshop sponsored by the National Eye Institute (NEI) Audacious Goals Initiative (AGI).

NIH scientists deploy CRISPR to preserve photoreceptors in mice

Tue, 03/14/2017 - 18:58

Silencing a gene called Nrl in mice prevents the loss of cells from degenerative diseases of the retina, according to a new study. The findings could lead to novel therapies for preventing vision loss from human diseases such as retinitis pigmentosa. The study was conducted by researchers at the National Eye Institute (NEI), part of the National Institutes of Health, and was published online today in Nature Communications.  

NIH scientists deploy CRISPR to preserve photoreceptors in mice

Tue, 03/14/2017 - 18:58

Silencing a gene called Nrl in mice prevents the loss of cells from degenerative diseases of the retina, according to a new study. The findings could lead to novel therapies for preventing vision loss from human diseases such as retinitis pigmentosa. The study was conducted by researchers at the National Eye Institute (NEI), part of the National Institutes of Health, and was published online today in Nature Communications.  

 

Breast cancer drug dampens immune response, protecting light-sensing cells of the eye

Mon, 03/13/2017 - 20:53

The breast cancer drug tamoxifen appears to protect light-sensitive cells in the eye from degeneration, according to a new study in mice. The drug prevented immune cells from removing injured photoreceptors, the light-sensitive cells of the retina in the back of the eye. The study, recently reported in the Journal of Neuroscience, suggests tamoxifen might work for the treatment of age-related macular degeneration (AMD) and retinitis pigmentosa (RP), blinding diseases that lack good treatment options.

Breast cancer drug dampens immune response, protecting light-sensing cells of the eye

Mon, 03/13/2017 - 20:53

The breast cancer drug tamoxifen appears to protect light-sensitive cells in the eye from degeneration, according to a new study in mice. The drug prevented immune cells from removing injured photoreceptors, the light-sensitive cells of the retina in the back of the eye. The study, recently reported in the Journal of Neuroscience, suggests tamoxifen might work for the treatment of age-related macular degeneration (AMD) and retinitis pigmentosa (RP), blinding diseases that lack good treatment options.

NIH scientists identify disorder causing blindness, deafness, albinism and fragile bones

Wed, 03/01/2017 - 21:06

Researchers at the National Eye Institute (NEI), part of the National Institutes of Health, have identified the genetic underpinnings of a rare disorder that causes children to be born with deafness, blindness, albinism and fragile bones. The newly recognized syndrome, COMMAD, affects children who inherit two mutations of a gene – one from each parent – each of whom is deaf due to another rare, genetic disorder called Waardenburg syndrome 2A. A paper documenting the first recognized cases of COMMAD appears in the American Journal of Human Genetics(link is external). 

NIH scientists identify disorder causing blindness, deafness, albinism and fragile bones

Wed, 03/01/2017 - 21:06

Researchers at the National Eye Institute (NEI), part of the National Institutes of Health, have identified the genetic underpinnings of a rare disorder that causes children to be born with deafness, blindness, albinism and fragile bones. The newly recognized syndrome, COMMAD, affects children who inherit two mutations of a gene – one from each parent – each of whom is deaf due to another rare, genetic disorder called Waardenburg syndrome 2A. A paper documenting the first recognized cases of COMMAD appears in the American Journal of Human Genetics(link is external). 

NIH scientists identify disorder causing blindness, deafness, albinism and fragile bones

Tue, 02/28/2017 - 13:46

Researchers at the National Eye Institute (NEI), part of the National Institutes of Health, have identified the genetic underpinnings of a rare disorder that causes children to be born with deafness, blindness, albinism and fragile bones. The newly recognized syndrome, COMMAD, affects children who inherit two mutations of a gene – one from each parent – each of whom is deaf due to another rare, genetic disorder called Waardenburg syndrome 2A.

Five innovations harness new technologies for people with visual impairment, blindness

Fri, 02/03/2017 - 16:34

During Low Vision Awareness Month, the National Eye Institute (NEI), part of the National Institutes of Health, is highlighting new technologies and tools in the works to help the 4.1 million Americans living with low vision or blindness. The innovations aim to help people with vision loss more easily accomplish daily tasks, from navigating office buildings to crossing a street.

Five innovations harness new technologies for people with visual impairment, blindness

Fri, 02/03/2017 - 16:34

During Low Vision Awareness Month, the National Eye Institute (NEI), part of the National Institutes of Health, is highlighting new technologies and tools in the works to help the 4.1 million Americans living with low vision or blindness. The innovations aim to help people with vision loss more easily accomplish daily tasks, from navigating office buildings to crossing a street.

Stem cell secretions may protect against glaucoma

Thu, 01/26/2017 - 21:15

A new study in rats shows that stem cell secretions, called exosomes, appear to protect cells in the retina, the light-sensitive tissue in the back of the eye. The findings, published in Stem Cells Translational Medicine, point to potential therapies for glaucoma, a leading cause of blindness in the United States. The study was conducted by researchers at the National Eye Institute (NEI), part of the National Institutes of Health.

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Stem cell secretions may protect against glaucoma

Thu, 01/26/2017 - 21:15

A new study in rats shows that stem cell secretions, called exosomes, appear to protect cells in the retina, the light-sensitive tissue in the back of the eye. The findings, published in Stem Cells Translational Medicine, point to potential therapies for glaucoma, a leading cause of blindness in the United States. The study was conducted by researchers at the National Eye Institute (NEI), part of the National Institutes of Health.

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Reconnecting Eye to Brain

Wed, 10/19/2016 - 20:29

Michael Crair, Yale University, and Carol Mason, Columbia University, have co-authored a report published online today in the Journal of Neuroscience. “Reconnecting Eye to Brain” is a comprehensive assessment of what scientists know about optic nerve development, regeneration, and reconnection. The report was based on input gathered during the Oct. 16, 2015, panel discussion, titled “Reconnecting Neurons in the Visual System,” sponsored by the National Eye Institute Audacious Goals Initiative (AGI). The panel comprised two dozen leading experts on neural development and regeneration. 

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Reconnecting Eye to Brain

Wed, 10/19/2016 - 20:29

Michael Crair, Yale University, and Carol Mason, Columbia University, have co-authored a report published online today in the Journal of Neuroscience. “Reconnecting Eye to Brain” is a comprehensive assessment of what scientists know about optic nerve development, regeneration, and reconnection. The report was based on input gathered during the Oct. 16, 2015, panel discussion, titled “Reconnecting Neurons in the Visual System,” sponsored by the National Eye Institute Audacious Goals Initiative (AGI). The panel comprised two dozen leading experts on neural development and regeneration. 

Language Undefined

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